Executive processes in Parkinson's disease: FDG‐PET and network analysis
Identifieur interne : 000170 ( France/Analysis ); précédent : 000169; suivant : 000171Executive processes in Parkinson's disease: FDG‐PET and network analysis
Auteurs : Catherine Lozza [France] ; Jean-Claude Baron [France, Royaume-Uni] ; David Eidelberg [États-Unis] ; Marc J. Mentis [États-Unis] ; Maren Carbon [États-Unis] ; Rose-Marie Marié [France]Source :
- Human Brain Mapping [ 1065-9471 ] ; 2004-07.
English descriptors
Abstract
It is assumed widely that the clinical expression of Parkinson's Disease (PD), both motor and cognitive, is subtended by topographically distributed brain networks. However, little is known about the functional neuroanatomy of executive dysfunction in PD. Our objective was to validate further in a PD group the use of network analysis to assess the relationship between executive processes and pathological disorganization of frontostriatal networks. We studied 15 patients with idiopathic PD, and 7 age‐matched normal controls, using resting [18F]fluorodeoxyglucose (FDG) and high‐resolution positron emission tomography (PET). We carried out network analysis on regional metabolic data to identify specific covariation patterns associated with motor and executive dysfunction. We detected two independent patterns relating respectively to the two clinical abnormalities. The first pattern (principal component 1) was topographically similar to that described previously in other PD populations. Subject scores for this pattern discriminated patients from controls and correlated significantly with bradykinesia ratings (P = 0.013, r = 0.655) in PD patients. The second pattern (principal component 2) was characterized by relative ventromedial frontal, hippocampal, and striatal hypometabolism, associated with mediodorsal thalamic hypermetabolism. In the PD group, scores from this pattern correlated with scores on the conditional associative learning (CAL; P = 0.01, r = 0.690) and the Brown Peterson paradigm (BPP; P = 0.017, r = −0.651) tests, respectively assessing strategy and planning, and working memory. According to these findings, the networks subserving bradykinesia and executive dysfunction in PD seems to be topographically distinct and to involve different aspects of subcortico‐cortical processing. Hum. Brain Mapping 22:236–245, 2004. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/hbm.20033
Affiliations:
- France, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, État de New York
- Caen, Cambridge
- Université de Cambridge
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 001251
- to stream Main, to step Curation: 001048
- to stream Main, to step Exploration: 001637
- to stream France, to step Extraction: 000170
Links to Exploration step
ISTEX:529CFAF614C17C047BD7C7BE5C7894535011589ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Executive processes in Parkinson's disease: FDG‐PET and network analysis</title><author><name sortKey="Lozza, Catherine" sort="Lozza, Catherine" uniqKey="Lozza C" first="Catherine" last="Lozza">Catherine Lozza</name></author><author><name sortKey="Baron, Jean Laude" sort="Baron, Jean Laude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name></author><author><name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J." last="Mentis">Marc J. Mentis</name></author><author><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name></author><author><name sortKey="Marie, Rose Arie" sort="Marie, Rose Arie" uniqKey="Marie R" first="Rose-Marie" last="Marié">Rose-Marie Marié</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:529CFAF614C17C047BD7C7BE5C7894535011589A</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/hbm.20033</idno><idno type="url">https://api.istex.fr/document/529CFAF614C17C047BD7C7BE5C7894535011589A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001251</idno><idno type="wicri:Area/Main/Curation">001048</idno><idno type="wicri:Area/Main/Exploration">001637</idno><idno type="wicri:Area/France/Extraction">000170</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Executive processes in Parkinson's disease: FDG‐PET and network analysis</title><author><name sortKey="Lozza, Catherine" sort="Lozza, Catherine" uniqKey="Lozza C" first="Catherine" last="Lozza">Catherine Lozza</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 320, Centre Cyceron, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Equipe Universitaire‐Université de Basse Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Baron, Jean Laude" sort="Baron, Jean Laude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 320, Centre Cyceron, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J." last="Mentis">Marc J. Mentis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Marie, Rose Arie" sort="Marie, Rose Arie" uniqKey="Marie R" first="Rose-Marie" last="Marié">Rose-Marie Marié</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 320, Centre Cyceron, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Equipe Universitaire‐Université de Basse Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Brain Mapping</title><title level="j" type="abbrev">Hum. Brain Mapp.</title><idno type="ISSN">1065-9471</idno><idno type="eISSN">1097-0193</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-07">2004-07</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="236">236</biblScope><biblScope unit="page" to="245">245</biblScope></imprint><idno type="ISSN">1065-9471</idno></series><idno type="istex">529CFAF614C17C047BD7C7BE5C7894535011589A</idno><idno type="DOI">10.1002/hbm.20033</idno><idno type="ArticleID">HBM20033</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1065-9471</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>FDG‐PET</term><term>Parkinson's disease</term><term>executive functions</term><term>network analysis</term><term>working memory</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is assumed widely that the clinical expression of Parkinson's Disease (PD), both motor and cognitive, is subtended by topographically distributed brain networks. However, little is known about the functional neuroanatomy of executive dysfunction in PD. Our objective was to validate further in a PD group the use of network analysis to assess the relationship between executive processes and pathological disorganization of frontostriatal networks. We studied 15 patients with idiopathic PD, and 7 age‐matched normal controls, using resting [18F]fluorodeoxyglucose (FDG) and high‐resolution positron emission tomography (PET). We carried out network analysis on regional metabolic data to identify specific covariation patterns associated with motor and executive dysfunction. We detected two independent patterns relating respectively to the two clinical abnormalities. The first pattern (principal component 1) was topographically similar to that described previously in other PD populations. Subject scores for this pattern discriminated patients from controls and correlated significantly with bradykinesia ratings (P = 0.013, r = 0.655) in PD patients. The second pattern (principal component 2) was characterized by relative ventromedial frontal, hippocampal, and striatal hypometabolism, associated with mediodorsal thalamic hypermetabolism. In the PD group, scores from this pattern correlated with scores on the conditional associative learning (CAL; P = 0.01, r = 0.690) and the Brown Peterson paradigm (BPP; P = 0.017, r = −0.651) tests, respectively assessing strategy and planning, and working memory. According to these findings, the networks subserving bradykinesia and executive dysfunction in PD seems to be topographically distinct and to involve different aspects of subcortico‐cortical processing. Hum. Brain Mapping 22:236–245, 2004. © 2004 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>État de New York</li></region><settlement><li>Caen</li><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Lozza, Catherine" sort="Lozza, Catherine" uniqKey="Lozza C" first="Catherine" last="Lozza">Catherine Lozza</name></noRegion><name sortKey="Baron, Jean Laude" sort="Baron, Jean Laude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name><name sortKey="Lozza, Catherine" sort="Lozza, Catherine" uniqKey="Lozza C" first="Catherine" last="Lozza">Catherine Lozza</name><name sortKey="Marie, Rose Arie" sort="Marie, Rose Arie" uniqKey="Marie R" first="Rose-Marie" last="Marié">Rose-Marie Marié</name><name sortKey="Marie, Rose Arie" sort="Marie, Rose Arie" uniqKey="Marie R" first="Rose-Marie" last="Marié">Rose-Marie Marié</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Baron, Jean Laude" sort="Baron, Jean Laude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name></region></country><country name="États-Unis"><region name="État de New York"><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name></region><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name><name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J." last="Mentis">Marc J. Mentis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000170 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000170 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:529CFAF614C17C047BD7C7BE5C7894535011589A
|texte= Executive processes in Parkinson's disease: FDG‐PET and network analysis
}}
| This area was generated with Dilib version V0.6.23. |  |